En Sabah Nur / Apocalypse is the nigh immortal first mutant, born roughly 5000 years ago in Egypt. He joined Demonizer and works with them, rather than for them, because their emperor's lust for power and warped beliefs fit with the "survival-of-the-fittest" philosophy by which Apocalypse abides.
"The Morning Light" is a remix of Apocalypse's boss theme in Marvel Super Heroes VS Street Fighter.
- "Everything they've built will fall! And from the ashes of their world, we'll build a better one!" - pre-battle quote
- "You are lost because you follow blind leaders. Yes!"
- David Kaye reprises the voice of Apocalypse like in X-Men: Evolution, giving him the same voice as Megatron in Beast Wars. When Apocalypse grows giant, he has the same robotic voice effect as Megatron does in Transformers Armada, Energon, and Cybertron.
- When Kiba Ranger first sees Apocalypse, he'll say "Why am I having a strange case of deja vu?", as a reference to how Apocalypse's movie costume reminded some people of Ivan Ooze.